Protein Details: ATP-sensitive inward rectifier potassium channel 10
Protein ID
ICDB_Pro_0567
Protein Name
ATP-sensitive inward rectifier potassium channel 10
Gene Name
Kcnj10; Kab-2
Organism
Rattus norvegicus (Rat)
Length
379 amino acids
AlphaFoldDB
AF-P49655-F1-model_v4.pdb
Function
May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised; the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney; together with KCNJ16; mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity)
Sequence
PDB Structures
Ligand Binding
Binding Site
210..217
Disease
Location
Predominantly expressed in the brain; including in glial cells of the cerebellum and forebrain. Expressed at lower levels in the kidney; and other peripheral tissues.
DOI ID
10.1074/jbc.270.27.16339; 10.1073/pnas.92.15.6753
RefSeq
NP_113790.2; XP_008767959.1; XP_017454263.1